{"id":533,"date":"2023-05-06T03:58:59","date_gmt":"2023-05-06T03:58:59","guid":{"rendered":"http:\/\/src.cikeys.com\/2023\/?page_id=533"},"modified":"2023-05-06T04:03:08","modified_gmt":"2023-05-06T04:03:08","slug":"investigating-mechanisms-natural-variation-and-sex-differences-in-response-to-serotonin","status":"publish","type":"page","link":"https:\/\/src.cikeys.com\/2023\/conference-schedule\/poster-presentations-session-2\/investigating-mechanisms-natural-variation-and-sex-differences-in-response-to-serotonin\/","title":{"rendered":"Investigating Mechanisms, Natural Variation, and Sex Differences in Response to Serotonin"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Lendin Stell Santiago, Kris Korpontinos, Delyar Khosroabadi, Annabelle Tran, Jamie Ferns, &amp; Dr. Gareth Harris<\/h2>\n\n\n\n<!--more-->\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h3 class=\"wp-block-heading\">Abstract<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Mood disorders, such as depression, affect over 40 million people in the US. Despite the use of an array of therapeutics for mood disorders, current understanding of the mechanisms underlying these processes and the specific targets of each therapy remains unclear. This results in variable success of the existing treatments, along with very little specificity toward an individual. More recently, there has been a deeper focus on understanding serotonin targets involved in mood and mood disorders. We use the nematode, Caenorhabditis elegans, to investigate the behavioral effects of serotonin and the neural mechanisms and intracellular pathways that mediate serotonin\u2019s effect on the brain. Our present study specifically investigates, 1) the novel targets of serotonin, and 2) how serotonin-dependent behaviors may vary across different species within the Caenorhabditis genus. We have found that known serotonin effects on worm behaviors including paralysis and stimulated egg laying require specific brain signals, and were significantly different across worm species that originate from distinct geographical locations. This implies the possibility of characterizing intracellular pathways and the factors that contribute to the differing behaviors, to better understand the extent of pharmacological drug specificity toward an individual suffering from mood disorders. We intend to continue the discovery of serotonin targets, and how these effects differ across nematodes, to assess the fundamental variation in alternate behavioral responses to both serotonin and serotonin targeting therapeutics, which continues to be highly important in understanding human neuropsychiatric disease, like depression, addiction, and bipolar disorder.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<h3 class=\"wp-block-heading\">Details<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Session 2<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3:00pm \u2013 4:30pm<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Grand Salon<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>HSI-SMART<\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"wp-block-comments\">\n\n\n\n\n\n\t<div id=\"respond\" class=\"comment-respond wp-block-post-comments-form\">\n\t\t<h3 id=\"reply-title\" class=\"comment-reply-title\">Leave a Reply <small><a rel=\"nofollow\" id=\"cancel-comment-reply-link\" href=\"\/2023\/wp-json\/wp\/v2\/pages\/533#respond\" style=\"display:none;\">Cancel reply<\/a><\/small><\/h3><form action=\"https:\/\/src.cikeys.com\/2023\/wp-comments-post.php\" method=\"post\" id=\"commentform\" class=\"comment-form\"><p class=\"comment-notes\"><span id=\"email-notes\">Your email address will not be published.<\/span> <span class=\"required-field-message\">Required fields are marked <span class=\"required\">*<\/span><\/span><\/p><p class=\"comment-form-comment\"><label for=\"comment\">Comment <span class=\"required\">*<\/span><\/label> <textarea id=\"comment\" name=\"comment\" cols=\"45\" rows=\"8\" maxlength=\"65525\" required><\/textarea><\/p><p class=\"comment-form-author\"><label for=\"author\">Name <span class=\"required\">*<\/span><\/label> <input id=\"author\" name=\"author\" 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name='comment_post_ID' value='533' id='comment_post_ID' \/>\n<input type='hidden' name='comment_parent' id='comment_parent' value='0' \/>\n<\/p><p style=\"display: none !important;\" class=\"akismet-fields-container\" data-prefix=\"ak_\"><label>&#916;<textarea name=\"ak_hp_textarea\" cols=\"45\" rows=\"8\" maxlength=\"100\"><\/textarea><\/label><input type=\"hidden\" id=\"ak_js_1\" name=\"ak_js\" value=\"221\"\/><script>\ndocument.getElementById( \"ak_js_1\" ).setAttribute( \"value\", ( new Date() ).getTime() );\n<\/script>\n<\/p><\/form>\t<\/div><!-- #respond -->\n\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Lendin Stell Santiago, Kris Korpontinos, Delyar Khosroabadi, Annabelle Tran, Jamie<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":112,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[27,5,3,10],"tags":[21,28],"class_list":["post-533","page","type-page","status-publish","hentry","category-hsi-smart","category-poster","category-presentations","category-session-2-poster","tag-biology","tag-hsi-smart"],"_links":{"self":[{"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/pages\/533","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/comments?post=533"}],"version-history":[{"count":2,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/pages\/533\/revisions"}],"predecessor-version":[{"id":601,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/pages\/533\/revisions\/601"}],"up":[{"embeddable":true,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/pages\/112"}],"wp:attachment":[{"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/media?parent=533"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/categories?post=533"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/tags?post=533"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}