{"id":382,"date":"2023-05-06T02:39:15","date_gmt":"2023-05-06T02:39:15","guid":{"rendered":"http:\/\/src.cikeys.com\/2023\/?page_id=382"},"modified":"2023-05-06T05:33:44","modified_gmt":"2023-05-06T05:33:44","slug":"the-role-of-acetylcholine-dysfunction-in-huntingtons-disease","status":"publish","type":"page","link":"https:\/\/src.cikeys.com\/2023\/conference-schedule\/poster-presentations-session-1\/the-role-of-acetylcholine-dysfunction-in-huntingtons-disease\/","title":{"rendered":"The Role of Acetylcholine Dysfunction in Huntington\u2019s Disease"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Paige Travis, Daniela Orozco, Anthony Strohbusch, Gabriel Vargas-Castillo, Dr. Sonsoles de Lacalle, Dr. Gareth Harris, Dr. Beatrice de Oca, &amp; Dr. Hugo Tapia<\/h2>\n\n\n\n<!--more-->\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h3 class=\"wp-block-heading\">Abstract<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Huntington&#8217;s Disease (HD) is a severe neurodegenerative condition with a wide array of symptoms, including motor and cognitive dysfunction. The neurotransmitter acetylcholine (ACh), which is necessary for voluntary and involuntary movement, memory, and other cognitive functions, is implicated in many symptoms of the disease. Huntington\u2019s Disease causes neural atrophy beginning in the basal ganglia, where cholinergic neurons are active and involved in movement signal output. Based on the foundation knowledge and observations in C. elegans from the HLTH 490 STEM bootcamp, we examine the literature, which includes human and mouse studies, to understand the role that ACh dysfunction plays in the presentation of HD. It is expected that abnormal cholinergic activity in the brain directly contributes to the motor, musculature, and cognitive symptoms observed in HD. This relationship is useful to understand as a model of how the brain communicates and creates purposeful action in a healthy system, and is also an area of research that can be targetted for treatment of HD symptoms in humans.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<h3 class=\"wp-block-heading\">Details<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Session 1<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>9:30am \u2013 11:00am<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Grand Salon<\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div data-client-id=\"\" 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reply<\/a><\/small><\/h3><form action=\"https:\/\/src.cikeys.com\/2023\/wp-comments-post.php\" method=\"post\" id=\"commentform\" class=\"comment-form\"><p class=\"comment-notes\"><span id=\"email-notes\">Your email address will not be published.<\/span> <span class=\"required-field-message\">Required fields are marked <span class=\"required\">*<\/span><\/span><\/p><p class=\"comment-form-comment\"><label for=\"comment\">Comment <span class=\"required\">*<\/span><\/label> <textarea id=\"comment\" name=\"comment\" cols=\"45\" rows=\"8\" maxlength=\"65525\" required><\/textarea><\/p><p class=\"comment-form-author\"><label for=\"author\">Name <span class=\"required\">*<\/span><\/label> <input id=\"author\" name=\"author\" type=\"text\" value=\"\" size=\"30\" maxlength=\"245\" autocomplete=\"name\" required \/><\/p>\n<p class=\"comment-form-email\"><label for=\"email\">Email <span class=\"required\">*<\/span><\/label> <input id=\"email\" name=\"email\" type=\"email\" value=\"\" size=\"30\" 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cols=\"45\" rows=\"8\" maxlength=\"100\"><\/textarea><\/label><input type=\"hidden\" id=\"ak_js_1\" name=\"ak_js\" value=\"20\"\/><script>\ndocument.getElementById( \"ak_js_1\" ).setAttribute( \"value\", ( new Date() ).getTime() );\n<\/script>\n<\/p><\/form>\t<\/div><!-- #respond -->\n\t<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Paige Travis, Daniela Orozco, Anthony Strohbusch, Gabriel Vargas-Castillo, Dr. Sonsoles<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":42,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[5,3,9],"tags":[24],"class_list":["post-382","page","type-page","status-publish","hentry","category-poster","category-presentations","category-session-1-poster","tag-health-science"],"_links":{"self":[{"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/pages\/382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/comments?post=382"}],"version-history":[{"count":2,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/pages\/382\/revisions"}],"predecessor-version":[{"id":784,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/pages\/382\/revisions\/784"}],"up":[{"embeddable":true,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/pages\/42"}],"wp:attachment":[{"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/media?parent=382"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/categories?post=382"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/src.cikeys.com\/2023\/wp-json\/wp\/v2\/tags?post=382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}