{"id":333,"date":"2022-05-05T21:17:29","date_gmt":"2022-05-05T21:17:29","guid":{"rendered":"https:\/\/src.cikeys.com\/2022\/?page_id=333"},"modified":"2023-02-15T05:24:20","modified_gmt":"2023-02-15T05:24:20","slug":"design-synthesis-and-evaluation-of-novel-nucleoside-analogues-as-anticancer-agents-to-target-ribonucleotide-reductase","status":"publish","type":"page","link":"https:\/\/src.cikeys.com\/2022\/design-synthesis-and-evaluation-of-novel-nucleoside-analogues-as-anticancer-agents-to-target-ribonucleotide-reductase\/","title":{"rendered":"Design, Synthesis, and Evaluation of Novel Nucleoside Analogues as\u00a0\u00a0Anticancer Agents to Target Ribonucleotide Reductase\u00a0"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">Sarah Tilley, Karla Leonard, Justine Garcia and Dr. Ahmed Awad<\/h3>\n\n\n\n<!--more-->\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Pancreatic cancer, specifically Pancreatic Ductal Adenocarcinoma (PDAC) has posed a multitude of difficulties for researchers and medical doctors alike. PDAC is difficult to detect, and oftentimes goes unnoticed until standard treatments such as surgery are not feasible or simply too risky. The leading treatment for pancreatic cancer, gemcitabine, has many issues associated with delivery due to the hydrophilic nature of the two fluorines located on the 2\u2019 Carbon of the ribose. Furthermore, when gemcitabine enters the cell, the nitrogenous portion of this cytidine nucleoside is often deaminated into uracil by cytidine deaminase which results in the exportation of the molecule out of the cell before it can reach the target protein, ribonucleotide reductase (RNR). To increase the efficacy of such molecules towards RNR, a series of novel nucleoside analogues modified at the 2\u2019 region of the ribose. These modifications include sulfamoyl functional groups to increase stability by hydrogen bonding to key amino acid residues, A605, T607, and S202 found in RNR. Molecular docking studies demonstrated that these novel molecules have higher binding affinity to the target enzyme, are capable of forming more hydrogen bonds, and in fact bind to these important residues found in the catalytic site of RNR. Furthermore, analysis through ADME and PASS predictions have shed more light on the potential of these novel nucleoside analogs as cancer therapeutics.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Presentation<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Session 2 \u2013 3:00p.m. \u2013 4:15p.m.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Room D \u2013 Sierra 2422&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Sarah Tilley, Karla Leonard, Justine Garcia and Dr. Ahmed Awad<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"categories":[20,27,28],"tags":[12],"class_list":["post-333","page","type-page","status-publish","hentry","category-oral","category-room-d","category-session-2","tag-chemistry","post"],"_links":{"self":[{"href":"https:\/\/src.cikeys.com\/2022\/wp-json\/wp\/v2\/pages\/333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/src.cikeys.com\/2022\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/src.cikeys.com\/2022\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/src.cikeys.com\/2022\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/src.cikeys.com\/2022\/wp-json\/wp\/v2\/comments?post=333"}],"version-history":[{"count":3,"href":"https:\/\/src.cikeys.com\/2022\/wp-json\/wp\/v2\/pages\/333\/revisions"}],"predecessor-version":[{"id":579,"href":"https:\/\/src.cikeys.com\/2022\/wp-json\/wp\/v2\/pages\/333\/revisions\/579"}],"wp:attachment":[{"href":"https:\/\/src.cikeys.com\/2022\/wp-json\/wp\/v2\/media?parent=333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/src.cikeys.com\/2022\/wp-json\/wp\/v2\/categories?post=333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/src.cikeys.com\/2022\/wp-json\/wp\/v2\/tags?post=333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}